【作者】 谢树森； 李步洪； 陆祖康；

【Author】 Xie Shusen~1 Li Buhong~(1,2) Lu Zukang~2 ~1(Biomedical Optics Laboratory, Institute of Laser, Fujian Normal University, Fuzhou 350007, China) ~2(National Research Center of Engineering and Technology for Optical Instrumentation, Zhejiang University, Hangzhou 310027, China)

【机构】 福建师范大学激光研究所生物医学光学实验室； 浙江大学国家光学仪器工程技术研究中心；

【摘要】 用传统鼻咽镜的白光光源传输系统,建立一套用于鼻咽癌诊断与定位的激光诱导药物荧光成像装置。给出了系统的光学整体设计方法,还包括激光器出射光束与光纤高效率耦合技术及同光轴非接触两光纤间的光束耦合技术。光学模型实验结果表明:实验样机的灵敏度和成像衬比度都达到了临床应用的基本要求。更多还原

【Abstract】 A novel fluorescence imaging system for diagnosis and localization of nasopharyngeal carcinoma was presented, which coupled the excitation laser into the original white-light transmission system of conventional nasal endoscope. The design approach of the imaging system and ultimate schematic diagram were also illustrated. The design of optical imaging system mainly including the coupled technique with high efficiency between light source and optical fiber, and the directed coupled technique of two coaxial optical beam from different optical fiber without contact. As a result, the fluorescence and reflection white light from the target tissue surface are imaged by a nasal endoscope for diagnosis and localization of early nasopharyngeal carcinoma respectively, which can be alternately switched in real time for clinical examination purpose. Preclinical results indicate that the system can meet with the fundamental requirements for clinical application.更多还原