【作者】 陶林； 王春华； 张宏久； 李裕基；

【Author】 Tao Lin, Wang Chunhua, Zhang Hongjiu, and Li Yuji Shenzhen City Kangning Hospital, Shenzhen 518003, China

【机构】 深圳市计划生育服务中心； 深圳市康宁医院；

【摘要】 目的:研究氯丙咪嗪与帕罗西汀治疗早泄的疗效和副作用。方法:选择符合DSM-IV早泄诊断标准的病人80名,随机分为帕罗西汀和氯丙咪嗪两个治疗组,病人每天服用帕罗西汀20mg或氯丙咪嗪30mg,4周后用自行编制的问卷评价治疗结果。结果:帕罗西汀组有5例病人脱落,氯丙咪嗪组脱落7例,两组之间在疗效和起效时间方面没有明显差异,氯丙咪嗪组副作用略多于帕罗西汀组。结论:两种药都可以用于治疗早泄,鉴于大剂量服用氯丙咪嗪仍然有一定危险性,建议由有经验的精神科医生使用。更多还原

【Abstract】 Objective: To study the efficacy and side-effect of Paroxetine and clomipramine for treatment of premature ejaculation. Methods: 80 male outpatients with premeture ejaculation were randomly assigned to treated with Paroxetine(N = 40) or clomipramine(N = 40). Patients took paroxetine 20 mg/day or clomipramine 30 mg/day for 4 weeks. Results: hi Paroxetine group, 35 patients finished the study finally and ejaculation latency (EL) increased from 1.99±0.99 min to 9.17±5. 63 min. In clomipramine group 33 patients finished the study and EL increased from 1.38±0.9 min to 11.80±12.52 min. No statistically significant difference was found between the two groups( t = 1.129,df = 66, P > 0.05). Side effects of clomipramine group are slightly more than that of Paroxetine group. Conclusion: Efficacy of Paroxetine and clomipramine are similar in treatment of premature ejaculation, but the Paroxetine is safer than the clomipramine.更多还原