【作者】 马振武； 李梅香； 韩嫣； 王传升；

【Author】 MA Zhen-wu, LI Mei-xiang HAN Yan Wang Chuansheng (The second affliated hospital of xinxiang medical college.xinxiang HE-NAN 453002,China)

【机构】 新乡医学院第二附属医院；

【摘要】 目的:比较西酞普兰与丙米嗪治疗脑卒中后抑郁的疗效及不良反应。方法:将87例脑卒中后抑郁病人随机分2组,其中西酞普兰组44例(男性23例,女性21例;年龄64±11岁)给西酞普兰d1-2为10mg,以后20mg,po, qd;6周为一个疗程。丙米嗪组43例(男性24例,女性19例;年龄63±12岁),给丙米嗪d1-3 25mg,d4-6 50mg,d7 起75mg,po,bid;6周为一个疗程。结果:治疗后西酞普兰组总有效率为81．82％,丙米嗪组为81．40％,2组相比较无显著意义(p>0．05)。结论:西酞普兰可用于治疗脑卒中后抑郁,不良反应少。更多还原

【Abstract】 AIM:To compare the effects and adverse reactions of citalopram and imipramine in treating patients with post-stroke depressive disorderMETHODS:eighty-seven patients with post-stroke depressive disorder were randomly divided into two groups;44 patients (M23,F21, age 64a±s11a)were treated with citalopram d1-2 10mg,then from d3 on 20 mg,po qd for 6wk,and other 43 patients of imipramine group (M24,F19;age 63a±s12a) were treated with imipramine d1-3,25mg;d4-6,50mg and then from d7 on 75mg,po bid for 6wk. RESULTS:The curative effect was 81.82% in citalopram group and 81.40% in the imipramine group.There was no significant difference between two groups(p > 0.05).In addition,the adverse reactions in citalopram group was less than that in imipramine group.CONCLUSION: Citalopram has batter efficacy and less adverse reactions in the treatment of post-stroke depression.更多还原