【作者】 荀鹏程； 陈峰； 董晨； 钱国华； 赖德建； 孟继宏；

【Author】 Pengcheng Xun~a Feng Chen~a Chen Dong~b Guohua Qian~a Dejian Lai~c Jihong Meng~b (Department of Epidemiology & Biostatistics,School of Public Health,Nanjing Medical University,Nanjing,Jiangsu,P.R.China; b Department of Microbiology & Immunology,School of Medicine,Southeast University,Nanjing,Jiangsu,P.R.China; c Division of Biostatistics,School of Public Health,The University of Texas,Houston,TX,77030,USA.)

【机构】 南京医科大学公共卫生学院； 东南大学医学院； 美国德州大学公共卫生学院；

【摘要】 为比较片段对 HEV 全序列基因分型的代表性,本文构建了“记分法”并通过 Monte Carlo 模拟获取了记分统计量的经验分布并用于假设检验,结果显示“片段Ⅲ可以代表全序列用于 HEV 基因分型”,且获得了生物信息分析的支持。“记分法”是一种思维朴素、有效实用的 HEV 基因分型代表性片段筛选的统计学方法。更多还原

【Abstract】 To develop a statistical method for comparison of partial genomic regions in their representatives of full-length genome of Hepatitis E virus for genotyping,a score method was constructed to compare the candidate fragments with the whole genome through Monte Carlo simulation.It was statistically indicated that fragment Ⅲ might be a representative region of the whole genome of Hepatitis E Virus for genotyping, which was verified by the subsequent bioinformatical analysis.It may be concluded from this study that the score method is a simple,effective and practical one for comparing partial genomic regions with full-length genome of HEV strains for genotyping.更多还原