鼻咽癌及癌旁组织超微结构的形态定量研究

【作者】 杨兴龙； 申洪； 宗永生；

【机构】 第一军医大学病理教研室； 中山医科大学病理学教研室；

【摘要】 应用体视学技术,在超微结构水平,对人鼻咽部正常假复层纤毛柱状上皮、鼻咽癌旁异型增生/化生上皮和鼻咽癌三种上皮细胞核的形态改变进行了定量测试。用于定量分析的体视学参数包括Vvn、Svn、Nvn、Vve、vn、sn共6个参数。结果显示6个参数按正常鼻咽上皮→癌旁上皮→癌的顺序逐渐增大,且差异具有显著性。提示鼻咽癌的病理发展存在着一个由正常上皮→异型增生/化生→癌的逐步渐进的过程,异型增生/化生的上皮应做为癌前病变予以关注。更多还原

【Abstract】 Normal nasopharyngeal epithelia,para-cancerous nasopharyngeal carcinoma(NPC) epithelia and tissue of nasopharyngeal carcinoma cells were taken as studying samples.The morphological changes of above three epithelial cell-s nuclear were measured by means of stereological methods at electronic microscopical leves. Vvn、Svn、Nvn、Vve、vn and sn were calculated.The results showed that all above parameters were trended to increase from normal to epithelioma and the differences are significant among three groups, which indicated that the development of NPC exists a model that-from normal nasopharyngeal epithelia→atypical metaplastic/proliferating process→epithelia carcinoma.更多还原