【作者】 何永红； 唐永红； 谭石慈； 邢达；

【Author】 Yonghong He Yonghong Tang Shici Tan Da Xing Institute of Laser Life Science, South China Normal University, Guangzhou, 510631

【机构】 华南师范大学激光生命科学研究所；

【摘要】 本文提出并设计了一种新的肿瘤诊断方法——FCLA辅助的超声动力学荧光诊断。声敏剂(HpD)首先选择性地在肿瘤组织内积聚,再利用超声激发HpD产生声敏作用,结果是在肿瘤组织内产生大量单线态氧,利用FCLA和单线态氧反应产生化学发光(其峰值波长在532nm),再利用高灵敏度探测器检测此发光的二维分布,便可以达到肿瘤定位的目的。我们从实验上证明了FCLA辅助的声动力学荧光诊断方法的可行性,得到了动物肿瘤模型的较清晰的诊断图象。这种方法可望在临床肿瘤诊断上得到实际应用。更多还原

【Abstract】 We designed a novel tumor diagnosis method named FCLA assisted sonodynamic diagnosis. In this method, sonosensitizer selectively bounded to the tumor tissues, then ultrasound can excite sensitizer to produce singlet oxygen (O2). The O2 can react with FCLA (5-Fluoresceinyl Cypridina Luminescent Analog) to emit chemiluminescence at the peak wavelength 532nm, thus we can use a high sensitivity detector to image the emission from FCLA to make a localization of the cancer. This is a novel idea proposed by our group, its feasibility was proved by our experiments, and a clear diagnosis image was obtained in the experiments in vivo.更多还原