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灵芝多糖对小鼠糖耐量的影响

Effects of Ganoderma Lucidum Polysaccharides on the glucose tolerance in mice

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【作者】 何敏吴锋徐济良

【Author】 He Min, Wu Feng, Xu Ji-liang Department of pharmacology, Nantong Medical College, Nantong 226001

【机构】 南通大学医学院药理学教研室

【摘要】 目的:初步探讨灵芝多糖对正常和糖尿病小鼠糖耐量的影响。方法:采用腹腔注射四氧嘧啶(200mg/kg)诱导小鼠造成糖尿病模型,分别观察单次给予0.5、1.5g/kg灵芝多糖后,正常和糖尿病小鼠糖耐量的改变。结果:灵芝多糖0.5g/kg仅能显著降低糖尿病小鼠餐后1 h和2h血糖,而灵芝多糖1.5g/kg对正常和糖尿病小鼠餐后1 h和2h血糖均有显著降低作用。结论:灵芝多糖能改善正常和四氧嘧啶糖尿病小鼠糖耐量。

【Abstract】 Objective: To investigate the effects of Ganoderma Lucidum Polysaccharides(GLPs) on the glucose tolerance in normal and diabetic mice. Methods: Diabetic mice model was induced by Alloxan (200mg / kg, ig.). Normal or diabetic mice were given a single dose of GLPs 0.5, 1.5g/kg by ig. and the changes of glucose tolerance were observed respectively. Results: GLPs 0.5g/kg could significantly lower the serum glucose levels at 1h and 2h after glucose administration in diabetic mice. However, GLPs 1.5g/ kg has hypoglycemic effects on serum glucose levels at 1h and 2h in normal or diabetic mice. Conclusion: GLPs can improve the glucose tolerance in normal and diabetic mice induced by Alloxan.

【关键词】 灵芝多糖糖尿病血糖小鼠
【Key words】 Ganoderma LucidumPolysaccharidesdiabetesserum glucosemice
  • 【会议录名称】 首届药用真菌产业发展暨学术研讨会论文集
  • 【会议名称】首届药用真菌产业发展暨学术研讨会
  • 【会议时间】2005-04
  • 【会议地点】中国南通
  • 【分类号】R285.5
  • 【主办单位】中国菌物学会药用真菌专业委员会、江苏省南通市人民政府
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