【作者】 何敏； 吴锋； 徐济良；

【Author】 He Min, Wu Feng, Xu Ji-liang Department of pharmacology, Nantong Medical College, Nantong 226001

【机构】 南通大学医学院药理学教研室；

【摘要】 目的:初步探讨灵芝多糖对正常和糖尿病小鼠糖耐量的影响。方法:采用腹腔注射四氧嘧啶(200mg/kg)诱导小鼠造成糖尿病模型,分别观察单次给予0.5、1.5g/kg灵芝多糖后,正常和糖尿病小鼠糖耐量的改变。结果:灵芝多糖0.5g/kg仅能显著降低糖尿病小鼠餐后1 h和2h血糖,而灵芝多糖1.5g/kg对正常和糖尿病小鼠餐后1 h和2h血糖均有显著降低作用。结论:灵芝多糖能改善正常和四氧嘧啶糖尿病小鼠糖耐量。更多还原

【Abstract】 Objective: To investigate the effects of Ganoderma Lucidum Polysaccharides(GLPs) on the glucose tolerance in normal and diabetic mice. Methods: Diabetic mice model was induced by Alloxan (200mg / kg, ig.). Normal or diabetic mice were given a single dose of GLPs 0.5, 1.5g/kg by ig. and the changes of glucose tolerance were observed respectively. Results: GLPs 0.5g/kg could significantly lower the serum glucose levels at 1h and 2h after glucose administration in diabetic mice. However, GLPs 1.5g/ kg has hypoglycemic effects on serum glucose levels at 1h and 2h in normal or diabetic mice. Conclusion: GLPs can improve the glucose tolerance in normal and diabetic mice induced by Alloxan.更多还原