【作者】 郭俊霞； 郑建全； 雷萍； 高岩峰； 陶陶； 金宗濂；

【Author】 GUO Jun-xia ZHENG Jian-quan LEI Ping GAO Yan-feng TAO Tao JIN Zong-lian (Beijing Key Laboratory of Bioactive Substances and Functional Foods,Beijing Union University Beijing 100083,China)

【机构】 北京联合大学生物活性物质与功能食品北京市重点实验室；

【摘要】 目的：探讨红曲的降压机制。方法和结果：在离体血管环,去甲肾上腺素(NE) 预刺激使血管收缩后加入红曲5mg/ml 可明显舒张血管,舒张百分比为(70．84±14．74)%。这一舒张血管作用与血管内皮完整度无关。加入吲哚美辛(Indo),阻断前列腺环素(PGI) 生成,对红曲的舒张血管作用没有影响(P＞0．05)。而加入左旋硝基精氨酸(L-NNA)阻断平滑肌细胞的 NO 合成,则可明显抑制红曲的舒张血管作用(P＜0．05)。红曲可使 CaCl2、 KCl 和 NE 量效曲线均明显右移(P＜0．05),表明红曲可抑制细胞膜钙通道,包括电位调控性钙通道(VOC)和受体调控性钙通道(ROC)。NE 收缩血管反应中 Ca2+来自细胞内和细胞外, 红曲对细胞内钙引起的收缩没有影响,但可明显抑制细胞外钙引起的收缩。结论：红曲可通过刺激平滑肌细胞产生 NO 和抑制钙通道而引起血管舒张,这可能是其降压的主要血管机制。更多还原

【Abstract】 Objectives:The hypotensive effect of monascus was studied by rat aortic rings. Methods and results:Monascus caused distinct relax precontraction was obviously reduced in the presence of NG-nitro-L-arginine(L-NNA,1×10^-4mol/L).While indomethacin(1×10^-6mol/L) did not affect the tension of the aortic rings.These results showed that monascus could relax aortic rings contracted with or without endothelium by NE(3.0×10^-7 mol/L).The relaxation percentage was （70.84±14.74）%.And the relaxation had no relation with endothelium.The monascus-induced relax resulted from increase the production of NO in smooth muscle,but not in endothelium in rat aortic rings.By adding monascus in advance,cumulative concentration-response curves of rat aortic rings were shifted downwards by CaCl2,KCl and NE.Monascus had a repressive effect on the contraction induced by extracellular calcium whereas no effect by intracellular calcium in aortic rings.These results showed that monascus could block the inward flow of calcium by voltage operative channel （VOC） and receptor operative channel （ROC）.Conclusives:Monascus could induce relaxation of aortic rings by increasing NO in smooth muscle and blocking inward flow of calcium.That was probably the main vascular mechanism of monascus hypotensive effect.更多还原