PKCs promotes ceramide-induced apoptosis in PC12 cells by decreasing the ratio of Bcl2/Bax involved in a Ca²⁺- dependent pathway and NF-κB activation

【作者】 金道忠； 朱兴族；

【机构】 中国科学院上海药物研究所；

【摘要】 <正>This study investigated the rele of PKCs on ceramide-induced apoptosis in Rat phaeochromocytoma PC 12 cells. Exogenous C6-ceramide induced apoptosis in PC 12 cells in a concentration-dependent way (5-20μmol/L). It failed to change the anti-apoptosis protein Bc12 and proapoptosis protein Bax expression at 12 h. Phorbol 12-myristate 13-acetate (PMA), a PKCs activator, failed to change the survive of PC12更多还原