【作者】 李芳； 朱红卫；

【Author】 Li Fang Zhu Hong-Wei The Fourth Hospital of Hebei medical university & Hebei provincial tumor hospital, Shijiazhuang, 050011, China

【机构】 河北医科大学第四医院暨河北省肿瘤医院；

【摘要】 目的:化疗是治疗癌症的有效方法,静脉化疗是将化疗药通过外周静脉输入体内,随血液循环带到病灶处,从而杀灭癌细胞,达到治疗的目的。而外周静脉持续滴注化疗药,是采用一次性微量止痛泵持续静脉缓慢滴注强刺激的化疗药,易造成血管平滑肌的痉挛,血管内膜的损伤,从而造成血管的损伤等导致不同程度的静脉炎发生。本研究采用50％硫酸镁对80例宫颈癌化疗的患者进行湿敷评估50％硫酸镁湿敷预防化疗药致外周静脉炎的疗效。方法:将2005年2月25 日到2005年12月30日之间住院的80例宫颈癌化疗患者按住院时间的顺序分成对照组和实验组。两组均在滴注化疗药物时(生理盐水120毫升+氟脲嘧啶2．0)用一次性微量止痛泵持续外周静脉注射,48小时后再加入同等药量,共持续96小时。实验组在开始滴注化疗药时,用4×6厘米大小的50%硫酸镁湿纱布放于穿刺针上方血管的位置,纱布要充分湿透却不滴水,共96小时,对照组不给于任何处理。结果观察穿刺部位有无红肿、疼痛。出现红肿、疼痛为静脉炎。实验组疼痛25％、红肿为55％,对照组疼痛42．5％、红肿90％。将收集到的资料经统计学分析,用x2检验。疼痛x2=6．125,p <0．05,差别有显著意义。血管红肿比较x2=11．529,p<0． 001,有极显著意义。实验组的疼痛、红肿发生率明显低于对照组,两组对比经统计学处理差异有显著性意义。结论:本研究使用50％硫酸镁对80例宫颈癌患者湿敷的效果进行了对比研究。其中实验组40例进行化疗的同时给予50％硫酸镁湿敷,对照组不给予任何干预。结果表明两组疼痛比较x2=6． 125,p<0．05,差别有显著意义。血管红肿比较x2=11．529, p<0．001,有极显著意义。说明采用50％硫酸镁湿敷可有效减轻疼痛。减少血管红肿的发生,能促进局部组织水肿的消失,可保护静脉,能有效地预防静脉炎的发生。更多还原

【Abstract】 Objective: To observe the effects of 50%magnesium sulfate for the prevent of phlebitis during the chemical treatment of 80cases of cervical carcinoma. Methods: we choose 40 cases of patients with cervical as the experimental group and another 40cases of patients with cervical carcinoma as the control group. Gauze of 50%magnesium sulfate was wet compressed on the site of puncture over the puncture needle until the instillation was over or completed. No such methods was done on the control group. Then redden swelling or pain feeling were observed or asked and recorded.X2-test method was used to analysis the results. Results: (1)Redden swelling: X2=11. 529,p<0.001,the difference was high If significant.(2)Pain feeling : X2=6.125 p<0.05,the difference was significant. Conclusions, Our study suggest that wet compressing with 50%magnesium sulfate can relax the blood vessel, and improve vasodilator. Persistent wet application with 50%magnesium sulfate was an effective method which could prevent the occurrences of phlebitis during chemical treatment on the patients with cervical carcinoma.更多还原