非小细胞肺癌时辰化疗的护理

【作者】 肖春莲； 刘虹；

【机构】 深圳市宝安区人民医院呼吸科；

【摘要】 目的:对比观察顺铂(DDP)联合羟基喜树碱 (HCPT)时辰化疗与常规化疗在同时期化疗应用过程中对晚期非小细胞肺癌的疗效。方法:选择药物的药效峰值时间给药, 顺铂于6pm用药,羟基喜树碱于4pm用药;将50例晚期非小细胞肺癌患者随机分为时辰化疗组(CC组)27例,常规化疗组(RC组)23例。结果:观察组中CR率18．5％(CR+PR) 66．7％,对照组中C R率8．7％,(CR+PR)39．1％。两组的有效率有显著性差异(P<0．05),骨髓抑制,消化道反应亦有显著性差异(P<0．05),结论:顺铂联合羟基喜树碱时辰化疗对晚期非小细胞的治疗的效果较好,毒副反应较低,给临床提供了一种新的治疗方法,值得推广。更多还原

【Abstract】 Objective: To study the defference between the effect of Chrono-Chemotherapy with DDP and HCPT and common therapy on late NSCLC. Methods: The chemotherapeutic medicine were given at peak time: DDP was given at 6pm, HCPT was given at 4pm. 50 patients were divided randomly into two groups: 27 patients in Chrono-Chemotherapy group,23 patients in common chemoratherapy group. Results: The CR of Chrono-Chemotherapy group is 18.5%, The (CR+PR) is 66.7%, The CR of the control is 8.7%, The (CR+PR) is 39.1%. There is an obviously difference of effective between the two groups (p<0.05). And there are also obviously difference of myelosuppression and digestive system reation (p <0.05). Conclusions: Chrono-Chemotherapy of DDP and HCPT had better effect on late NSCLC,and the toxic-ity is lower. Chrono-Chemotherapy is a new good therapeutic methed to promote..更多还原