【作者】 庞青松； 王静； 宋勇春； 王军； 王平；

【Author】 Pang Qing-Song Song Yong-Chun Wang Jun Wang Ping Radiotherapy department of Tianjin cancer hospital, Tianjin medical university 300060

【机构】 天津医科大学肿瘤医院放疗科；

【摘要】 目的:探讨放化疗联合治疗鼻腔恶性淋巴瘤的适宜放疗剂量并评价颈部预防照射的意义。方法:回顾性分析自1980—2000年我院收治的鼻腔恶性淋巴瘤患者75人,75 例患者在局部放疗前行CHOP方案为主的化疗3—5轮。依据局部放疗剂量的不同将病人分为45 Gy以下组,45—50 Gy组50—55 Gy组及55 Gy以上四组,比较各组间的5年局部控制率,五年生存率,五年无瘤生存率及副反应。依据是否行颈部预防性照射将病人分为两组,颈部预防性照射 25例, 37例未照射,并观察各组病人的颈淋巴结转移情况及生存率。结果:各组病人均能耐受治疗,放疗剂量45Gy 以下组局部控制率,五年生存率及五年无瘤生存率均低于其他三组(P<0．05)。而颈部预防照射组颈部转移率低于对照组(P<0．05),但两组间比较五年生存率无差别。结论:在与化疗联合的情况下,鼻腔恶性淋巴瘤的放疗剂量应大于 45Gy;颈部预防照射有利于降低颈部淋巴结转移率,但对生存率无影响。更多还原

【Abstract】 Objective: To study the proper radiotherapy dose of combined radiotherapy and chemotherapy and evaluate the value of preventive neck eradiation to nasal non-Hodgkinrymphoma. Methods: To analyze 75 patients of nasal non-Hodgkinlymphoma from 1980 to 2000 in retrospect,75 patients received CHOP trial chemotherapy for 3-5 cycles before local radiotherapy. Based on the different local radiotherapy dose,we divided the patients into 4 groups as less 45 Gy group, 45-50 Gy group, 50-55 Gy group and more than 55 Gy group and compared the local control rate,5 year disease free survival rate and side effects in the four groups. Depended on whether receiving the preventive neck eradiation or not ,we divided the patients into two groups,25 patients received preventive neck eradiation and 37 patients without preventive neck eradiation. We observed the metastasis in neck patients received preventive neck eradiation and survival rate between the two groups.Results: All the patients can finish the trial. The 5 year local control rate and 5 year disease free survival rate in 45 Gy group are lower than the other three groups. The patients received preventive neck eradiation achieved lower neck lymph node matastasis rate than the group without preventive neck eradiation but there are no significant difference in the survival rate in the two groups. Conclusion: When combined with chemotherapy, the radiotherapy dose in nasal non-Hodgkinlymphoma should be also more than 45 Gy. Preventive neck eradiation achieved lower neck lymph node matastasis rate but has no effect on the survival.更多还原