【作者】 杨进强； 李勇； 赵增仁； 邝钢； 范立侨； 焦锟； 赵群； 张志栋；

【Author】 Yang Jin-Qiang Li Yong Zhao Zeng-Ren et al. the Third Department of Surgery, the Fourth Hospital of Hebei Medical University & Hebei provincial tumor hospital, Shijiazhuang, 050011

【机构】 河北医科大学第四医院河北省肿瘤医院；

【摘要】 目地:检测胃癌患者血清血管内皮生长因子(VEGF) 水平和外周血T淋巴细胞嗜银蛋白(Ag—NORs)含量,探讨二者间的相关性及临床意义。方法:采用酶联免疫双抗夹心法 (ELISA)定量检测74例胃癌患者和32例健康人血清VEGF水平,同时检测外周血T淋巴细胞嗜银蛋白含量并进行相关分析。结果:胃癌患者血清VEGF水平(383．33±121．67 pg／ ml)明显高于健康人(142．86±71．29 pg／ml)(P<0．01),其水平与肿瘤大小、浸润深度、分化程度、有无转移、TNM分期有关(P<0．05或0．01), 而胃癌患者外周血T淋巴细胞 Ag-NORs含量(4．30±1．21％)明显低于健康人(7．65± 1．38％)(P<0．01),其含量与胃癌分化程度、有无转移、TNM 分期有关(P<0．05或0．01)。胃癌患者血清VEGF水平与外周血T淋巴细胞嗜银蛋白含量呈显著负相关(r=-0．659, P<0．01)。结论:胃癌患者血清VEGF水平和外周血T淋巴细胞Ag-NORs含量是评估胃癌恶性生物学行为的重要指标。二者密切相关,对评价机体肿瘤免疫功能具有重要的临床参考价值。更多还原

【Abstract】 Objective: To detect and explore the clinical implication and relationship between the serum level of vascular endothelial growth factor (VEGF) and content of T lymphocytes Ag-NORs in gastric carcinoma. Methods: The serum level of VEGF in 74 patients with gastric carcinoma and 32 healthy persons was measured with the methods of ELISA. At the same time, the content of T lymphocytes Ag-NORs was detected correspondingly. Results: The serum level of VEGF in patients with gastric carcinoma (383.33 ± 121.67 pg/ml) was significantly higher than that of healthy persons( 142.86 ± 71.29 pg/ml) (P < 0.01), and it correlated with the tumor size, infiltration depth, differentiation, metastasis and TNM stage (P < 0.05 or 0.01), But the content of T lymphocytes Ag-NORs in patients with gastric carcinoma(4.30 ± 1.21%) was dramatically lower than that of healthy persons(7.65 ± 1.38%) (P < 0.01), and it also correlated with tumor differentiation, metastasis and TNM stage (P < 0.05 or 0. 01), There was obvious negative correlation between them (r = - 0.659, P < 0.01). Conclusion: The serum level of VEGF and the content of T lymphocytes Ag-NORs may be the important indicators for evaluating the malignant biological behaviors of gastric carcinoma. They are closely correlated with each other and very important to appraise the body’ s immunological function.更多还原