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高强度聚集超声联合化疗治疗消化系统恶性肿瘤的疗效观察
High Intensity Focused Ultrasound in Combination with Chemotherapy:A Clinical Study for Digestive System Carcinoma
【作者】 穆庆霞; 王榕生; 黄普文; 卢凯华; 刘凌翔; 李燕敏; 束永前;
【Author】 Mu Qing-Xia Wang Rong-Sheng Huang Pu-Wen The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029
【机构】 南京医科大学第一附属医院肿瘤中心;
【摘要】 目的:探讨高强度聚集超声(high intensive fo— cused ultrasound,HIFU)联合化疗治疗消化系统恶性肿瘤的近期疗效。方法:2000年4月-2004年12月,对164例消化系统恶性肿瘤行全身静脉化疗和介入化疗的同时予HIFU 治疗,观察近期疗效及不良反应。结果:近期有效率(CP+PR )55.5%(91/164),其中CR8.5%(14/164),PR47.0%(77/ 164),主要不良反应有:消化道反应,骨髓抑制,神经毒性, 严重不良反应发生率5%。与单纯静脉化疗相比无明显增加。结论:HIFU联合化疗治疗消化系统恶性肿瘤近期疗效确切, 不增加化疗的毒付反应,患者能耐受,不失为有效治疗手段, 值得临床推广应用。
【Abstract】 Objective: To evaluate the recent curative efficacy and security of High intensity focused ultrasound (HIFU) in combination with chemotherapy in patients with digestive system carcinoma. Method: 164 patients with digestive system carcinoma were treated by HIFU(FEP-BY01) in combination with chemotherapy (intravenous or interventional) from Apr. 2000 to Dec. 2004. The recent curative efficacy and side-effect was observed. Results: The recent curative efficacy ( CP+PR) was 55.5% ( 91/ 164 ).Meanwhile, CR (complete response) was 8.5% (14/ 164 ), and PR(partial response) was 47.0% (77/164 ). Major toxicities included bone marrow depression, nausea, vomiting and neurotoxicity. The incidence of serious side effect was 5%. No significant differences between combination and chemotherapy single. Conclusion: This study shows that HIFU in combination with chemotherapy was a new efficent secure therapy for the patients with digestive system carcinoma. The side effect was not added and it can be well tolerated. Prospective trials should be warranted to determine the result
【Key words】 Chemotherapy; HIFU(High Intensity Focused Ultrasound); Digestive System Carcinoma;
- 【会议录名称】 第四届中国肿瘤学术大会暨第五届海峡两岸肿瘤学术会议论文集
- 【会议名称】第四届中国肿瘤学术大会暨第五届海峡两岸肿瘤学术会议
- 【会议时间】2006-10
- 【会议地点】中国天津
- 【分类号】R735
- 【主办单位】中国抗癌协会、中华医学会肿瘤学分会