【作者】 陈岳青； 黄秀珍； 陈文学；

【Author】 Chen Yue-Qing Huan Xiu-Zheng Chen Wen-Xue JiangXi province tumor hospital JiangXi NangChang 330029

【机构】 江西省肿瘤医院；

【摘要】 目的:探讨肿瘤体外药敏实验ATP生物荧光法 (ATP-TCA)在肺癌化疗中的应用。方法:应用ATP—TCA 对48例肺癌根治术标本,6例淋巴结活检标本,4例胸腔积液标本进行药敏检测。结果:ATP-TCA方法的可评估率为 95％。健择(GEM),诺维本(NVB),阿霉素(ADM)分别与顺铂(DDP)组成两药联合方案(GP,NP,AP),它们的敏感性分别为78％,64％,27％。化疗药物对肺癌的杀伤作用具有较强的个体差异性。结论:ATP-TCA是一种灵敏,可靠的肿瘤药敏感检测技术,可用于肺癌化疗中化疗药物的筛选。更多还原

【Abstract】 Objective: To study the application of ATP based bioluminescence tumor chemoesensitivity assay (ATP-TCA) in the chemotherapy of lung cancer. Methods: 48 lung cancer specimens from resection surgery, 6 lymph node biopsy and 4 pleural effusion were analyzed by ATP-TCA. Results: The evaluability was 95%.Three DDP containing combined chemotherapy regimens:GEN and DDP regimen(GP),NVB and DDP regimen(NP), ADM and DDP regimen (AP), the sensitive rate of GP, NP, AP was 78%, 64%, 27% respectively. The results suggested that differert lung cancer patients responded to chemotherapeutic drugs with individualized profiles. Conclusion: ATP-TCA is a filter for the screening of chemotherapeutic drugs against lung cancer with excellent sensitivity and reliability.更多还原