【作者】 张文超；

【Author】 Zhang Wen-Chao 1 department of head & neck, Affiliated cancer hospital of Tianjin medical university

【机构】 天津医科大学附属肿瘤医院头颈一科；

【摘要】 目的:分析伴有桥本氏病的甲状腺原发性淋巴瘤的临床、病理特点,探讨桥本氏病与原发性甲状腺淋巴瘤发病之间的关系及其诊断、治疗和预后。方法:回顾性分析39 例原发性甲状腺淋巴瘤中的25例同时患有桥本氏病患者, 总结临床资料。结果:分期I EA:9例,ⅡEA:12例,Ⅱ EB:3例,ⅢA1例。15例病理诊断明确伴发桥本氏病,10 例甲状腺功能检查支持伴有桥本氏病。共11例接受化疗,方案以COP、CHOP为主,7例同时接受放疗。随访期半年- 15年,失访2例,死亡5例。5年死亡率20％。结论:甲状腺桥本氏病与淋巴瘤的发生有相关性。治疗上对I、Ⅱ期病变应首选彻底手术可附加化疗及放疗,效果好;对于ⅢE 期以上或超甲状腺的病变采取化疗为主的综合治疗,若肿瘤残留,则预后差。更多还原

【Abstract】 objective: To analyze the clinicopathologic feature of the primary thyroid lymphoma accompanied by Hashimoto’s disease. To explore the relationship between thyroid lymphoma and Hashimoto’s disease and its diagnosis, treatment and prognosis. Methods: The clinical materials of 25 cases which have Hashimoto’s disease and thyroid lymphoma simultaneously were analyzed retrospectively in 39 thyroid lymphoma cases. Results: stage I EA: 9 cases, II EA: 12 cases, II EB: 3 cases, III A 1 case. 15 cases were diagnosed as Hashimoto’s disease by pathology, 10 cases were diagnosed as Hashimoto’s disease by examination of the function of thyroid. 11 cases were managed by chemotherapy, Main programs were COP and CHOP. 7 cases were managed by radiotherapy. The terms of following up were 6 months -15 years. 2 cases were losed, 5cases died. The rate of death was 20%. Conclusion: The morbility of lymphoma and Hashimoto’s disease were related. Surgery ablation and adjuvant chemotherapy and radiotherapy were selected for patients with stage I, II. Patients beyond stage III E should be treated with chemotherapy based combined modality.更多还原