【作者】 宋铁砾； 张建国； 于世平； 周刚； 申文江；

【Author】 Song Tie-Li Zhang Jian-Guo Yu Shi-Ping, et al. Peking University School of Stomatology, Beijing 100081 Peking University First Hospital, Beijing 100034

【机构】 北京大学口腔医学院； 北京大学第一临床医学院；

【摘要】 目的:初步总结放射性粒子定向植入治疗计划系统在治疗口腔颌面部恶性肿瘤中的应用价值。方法:对50例口腔颌面部恶性肿瘤患者,实施了放射性粒子定向植入治疗 (分别为术中即刻种植、术后经皮穿刺种植、单纯粒子种植)。治疗实施前设计种植计划。计划设计要点为:(1)采集靶区图象:所有图像资料来自术中所见的肿瘤范围或病变区CT 图像。(2)图象处理及制定治疗计划:将所采集图象输入计算机,应用治疗计划系统软件,在靶区模拟粒子种植,绘制出等剂量曲线并检测剂量分布,调整粒子位置使之分布合理,最后确定治疗计划。结果:治疗计划完成后,以TPS的检测软件进行检测,所用处方剂量涵盖的范围均包括了95％以上的靶面积或靶体积,达到了靶剂量区与病损区高度适形的要求。结论: 治疗计划系统为放射性离子定向植入治疗口腔颌面部肿瘤提供了重要的参考依据并为临床资料的总结分析建立了较为完善的基础。更多还原

【Abstract】 Objective: To describe the methods developed and implemented in treating oral and maxillofacial malignant tumor with radioactive seed orient implantation according to the characteristics of the tumor and to evaluate the effectiveness and feasibility of TPS in the treatment. Methods: Fifty subjects with oral and maxillofacial malignant tumor were selected and treated with radioactive seed implantation (intraoperative, postoperative or single seed implantation). The treatment plans were designed before implantation. The design includes: image collections of target volumes. All of the images were from tumors’ scope observed during operation or from CT. image management and design completion. All of the images were transferred into a computer. By using TPS software, seed implantation was simulated on the target volume, and then the equivalent dose curve was generated. After adjusting seed position, the plan was completed. Results: After completion of the treatment plan, the plan was detected by using TPS software and found that the prescription dose could cover 95% of the target proportion or target volume. Target dose area was well suited to lesions. Conclusion: TPS provides important reference for radioactive seed orient implantation in cure of oral and maxillofacial malignant tumor.更多还原