【作者】 胡万宁； 韩晓晨； 夏长金；

【Author】 Han Xiao-Chen Xia Chang-Jin Department of Head and Neck Tumor, Tangshan People’ s Hospital ,Tangshan, 063001,China

【机构】 唐山市人民医院头颈外科；

【摘要】 目的:研究分析HBME-1、CK19基因在甲状腺结节的表达状态及诊断价值。方法:回顾性分析天津肿瘤医院头颈科1975年1月至1998年1月收治的初治甲状腺乳头状癌行甲状腺癌联合根治术的有完整随访资料的93例患者临床、组织病理和免疫组织化学染色资料,同同期收治的15例结节性甲状腺肿,16例甲状腺腺瘤相比较。对常规HE染色证实上述病变的蜡块分别行HBME-1和CK19免疫组织化学染色。结果:93例甲状腺乳头状癌中,HBME-1基因阳性表达甲状腺乳头状癌为51例(54．8％),甲状腺良性病变为5例 (16．1％),CK19基因阳性表达甲状腺乳头状癌为39例(41．9％), 甲状腺良性病变为4例(12．9％)。两种基因在甲状腺乳头状癌和良性病变中的阳性表达均存在统计学差异。HBME-1、 CK19基因表达与甲状腺乳头状癌患者的性别、年龄、肿瘤大小、局部侵犯、颈淋巴结转移无明显相关性。结论: HBME-1、CK19基因在甲状腺乳头状癌中表达增强,在甲状腺结节的鉴别诊断中是有用的辅助手段。CK19在区分甲状腺乳头状癌和乳头状增生中是一个很好的标志物。更多还原

【Abstract】 Objective: Aberrant expressions of HBME-1, CK19 have been found in thyroid nodule. Therefore,we discussed their diagnostic value and the relationship between these expressions. Methods: During the period of January 1975 to January 1998,124 patients with thyroid masses(93 casesof papillary thyroid carcinoma, 15 cases of nodular goiter, 16 cases of follicular adenoma)who were never treated before were treated surgically in Department of Head & neck, Cancer Institute & Hospital Affiliating Tianjin Medical University. Archival tissue specimen of these 124 patients were examined for HBME-1, CK19 expression by way of immunohistochemical staining. Results: The rates of immuno-positive staining of HBME-1, CK19 in papillary thyroid carcinoma were54. 8%, 41.9% respectively, which were significantly higher than those in benign lesions (16.1%, 12.9%, respectively). No significant relationship was found between the expression of HBME-1, CK19 and the gender, age, tumor size, local invasion and cervical lymph node metastasis in thyroid papillary carcinoma. Conclusion: The expression levels of HBME-1, CK19 are significantly higher in papillary thyroid carcinoma than those in thyroid benign lesions, which may be of some diagnostic value in clinic. CK19 is a valuable marker in the distinction of papillary carcinoma from papillary hyperplasia.更多还原