【作者】 宋万新； 苏颖； 李贺；

【Author】 Song Wan-Xin Su Ying Li He NanYang Tumor Hospital, NanYang, 473061

【机构】 河南省南阳市肿瘤医院；

【摘要】 目的:探讨生物反应调节剂干扰素联合放疗对食管癌术后颈淋巴结转移癌的疗效、不良反应及预后。方法: 收治1997年2月至2002年5月发生颈淋巴结转移的食管癌手术后病人61例,其中食管胸上段癌8例,食管胸中段癌 37例,食管胸下段癌16例,术前均经病理证实。鳞癌57例, 其它癌4例,术前TNM分期I期3例,II期33例,III25例, 术后发生颈淋巴结转移癌的时间:1年以内者9例,5年以内者25例,5年以上者27例,全组病人均应用干扰素实体瘤体注射300万U／次,每周一次,共5—7周,联合Co60 放射治疗总剂量5700-7600CGY,均量6600 CGY,每周 5次,共6—7周,观察其转移癌的局部控制率、近期疗效、随访观察其生存率及预后。结果:放疗结束时PR、CR、NR 分别为44．3％(27／61)、45．9％(28／61)、9．8％(6／61), 总有效率为90．2％,中位随访时间20个月,其1、3、5年生存率分别为63．9％(39／61)、31．1％(19／61)、5％(3／ 61),全组病人出现发热反应者4例,体温均在38．5℃以下, 发生率为6．6％(4／61),对症处理后体温降至正常,出现白细胞下降12例,发生率为19．7％(12／61),对症治疗后恢复正常。余未发现无其它并发症。结论:干扰素联合放疗可以延长部分食管癌术后区域复发转移病人的生存时间,其中手术时TNM分散较早者预后较好,干扰素与放疗具有协同抗肿瘤作用,局部应用干扰素可直接抑制肿瘤细胞的生长与增殖,提高局部控制率,此项研究旨在探讨食管癌术后复发与转移的综合治疗模式。更多还原

【Abstract】 Objective: Discuss Curative effect ,bad response and condition after treatment of the interferon of biologic response modifiers,after treatment of post-operational neck lymph nodes transfer cancer to esophageal carcinoma associated with radiotherapy. Methods: During Feb.1997 to May.2002,All of 61 patients includes: 8 patients of up-esophageal carcinoma, 37 patients of midesophageal carcinoma, 16 patients of low-esophageal carcinoma, pathological test before operation. The time of transfer of neck lymph nodes: 9 patients in one-year , 25 patients in five years, 27 patients over five-year .All patients use that interferon inject to hypostatical tumor. Results: When the end of radiotherapy, PR, CR, NR were 44.3%(27/61), 45.9%(28/61) and 9.8%(6/61), all effect was 90.2%, 1-, 3-, 5-year survival rates were 63.9%(39/61), 31.1%(19/61) and 5% (3/61). Pyretic patients were 4, all of temperature below 38.5 ℃, recover normal body-temperature after processing. Decline of white blood cells were 12, existent rate was 19.7%. Concousion: it can prolong existent time of part of recurrence of Resistive tumour, partical application can directly control growth and propagate of tumorous cells, improve manipulative rates of local.更多还原