【作者】 万以叶； 宋荣峰；

【Author】 Wan Yi-Ye Song Rong-Feng No.3 Department of Medical Oncology Jiangxi Cancer hospital, Nanchang 330029.

【机构】 江西省肿瘤医院内三科；

【摘要】 目的:研究观察国产多西他赛联合顺铂治疗蒽环类药物化疗失败的转移性乳腺癌的疗效及安全性。方法:31例蒽环类药物治疗失败的转移性乳腺癌患者接受多西他赛联合顺铂方案治疗,多西他赛75mg／m3第一天;顺铂80mg／m2 分成三天使用,每周期评价疗效同时记录不良反应。结果所有患者均可评价疗效和不良反应,完全缓解(CR)2例, 部分缓解(PR)14例,有效率(CR+PR)51．6％,(16／31)。无严重不良反应导致死亡的患者,中性粒细胞减少是主要不良反应,Ⅲ-Ⅳ度占54．8％,脱发发生率42％。结论:多西他赛联合顺铂是治疗蒽环类耐药的转移性乳腺癌的有效方案, 其不良反应能够耐受。更多还原

【Abstract】 Objective :To evaluate the efficavy and toxicity of docetaxel-Cisplatin combination chemotherapy in patients with metastatic breast cancer who failed prior treatment with anthracyclin. Methods: thirty-one patients previously failured to anthraclin-based chemotherapy received of docetaxel plus cisplatin ,Docetaxl 75mg/m2 iv d1 ,Cisplatin 80mg/m2 ivgtt divice to d1-3 ,once every 3 weeks. Results: All patients were evaluated for response. The over all clinical response rate was 51.6% ,there were 2 complete response (CR) ,14 partial response(PR) ,6 stable disease and 9 progress disease. One hundred-eight cycles were evaluated for the toxicity,There was no serions adverse event lead to death. Major toxicity was neurotoxicity and alopecia. The incidence of grade III and IV of neurotoxicity were 57.1% .alopecia were 42%. Conclusion: The combination of docetaxel and Cisplatin is an effective regimen for the patients who failed prior treatment with anth racyclin. Overall toxicity was tolerable.更多还原