【作者】 罗素霞； 陈小兵； 肖毅军； 刘义兴；

【Author】 Chen Xiao-Bing Luo Su-Xia Xiao Yi-Jun Liu Yi-Xing Department of Internal Medicine, Henan Tumor Hospital, Henan zhengzhou 450008

【机构】 河南省肿瘤医院内科； 林州市肿瘤医院内科；

【摘要】 目的:观察卡培他滨(希罗达,Xeloda)联合国产紫杉醇(Pacilitaxel,PTX)治疗晚期胃癌的近期疗效及不良反应。方法:2003年6月～2005年10月,以此方案治疗晚期胃癌34例。全组化疗共110周期,中位周期数3周期(2-5周期)。完成2周期化疗后评价疗效,有效病例4周后确认。结果:CR 2例,PR 17例,SD 8例,PD 7例,总有效率 (CR+PR)为55．9％(19／34),主要不良反应为血液学毒性,恶心、呕吐等胃肠道反应和手足综合征,血液学毒性以白细胞减少为主,Ⅲ～Ⅳ度白细胞减少发生率为17．7％,非血液学毒性均是轻度且可逆的。结论:卡培他滨联合国产紫杉醇是治疗晚期胃癌有效而且毒性较小的化疗方案。更多还原

【Abstract】 Objeotive: To evaluate the effects and adverse reactions of combination chemotherapy with capecitabine (Xeloda) and domestic pacilitaxel (PTX) in the treatment of advanced gastric cancer. Methods: From June 2003 to October 2005,34 patients of advanced gastric cancer were treated with PTX and Xeloda combination regimen. A total of 110 cycles were administered with a median of 3 cycle per patient(range 2-5).Tumor assessment was done after 2 cycles and the effective cases were confirmed after 4 weeks. Results: 5 cases CR,17 cases PR,8 cases SD ,7 cases PO. The overall response rate was 55.9%.The median time of response duration was 4 months(range 2-10).The maijor adverse reaction are he-matology toxicity, nausea and vomiting and hand-to-foot syndrome. The main myelosuppression was WBC with grade III and IV neutropenia being in 11.7%. Non-hema-tologic toxicities were modest and recoverable on discontinuation of therapy. Conclusion: Xeloda and domestic PTX combination regimen is an effective and mild toxicity combined chemotherapy for advanced gastric cancer.更多还原