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醛氢叶酸钙与5氟脲嘧啶联合治疗晚期结肠癌临床观察

A clinical study of Advanced Colon Cancers Treated by Leucovirin and 5—Fluorouracilum

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【作者】 郑涛陈伟白桦

【Author】 Zheng Tao Chen Wei Bai Hua Dpet. of oncological medicine, the people’s Hospital Shen Zhen 518020

【机构】 深圳市人民医院肿瘤科

【摘要】 目的联合应用醛氢叶酸钙(CF)与氟脲嘧啶(5—Fu),观察该方案对转移性结肠癌的临床疗效和不良反应。方法采用CF每次200毫克,静滴2小时,5—Fu每次500mg/m~2,于CF滴注一半时静脉推注,每天一次,连用5天,21天后重复。结果PR4例(19.05%)、MRS例 (23.81%)、SD4例(19.05%)、PD8例(38.09%)。21例中除3例因病情恶化终止治疗,余18例化疗后临床症状均有减轻或消失,生活质量提高。随访中位生存期8月,有2例至今分别存活13个月、17个月。不良反应以胃肠道多见,其中食欲不振71.40%,口腔溃疡38.10%,恶性呕吐 23.80%,腹泻19.00%,骨髓抑制轻微,均为1~2级毒性反应,其它尚有皮肤色素沉着等。结论 CF加5—Fu联合治疗晚期结肠癌,疗效优于单用5—Fu,同时不良反应较小,患者多能耐受,并可减轻症状,提高生活质量及延长生存期.值得进一步研究。

【Abstract】 Purpose To observed the results and the side—effect of combination of CF and 5 —Fu regimen in patient with advanced colon cancer. Method: CF200mg i, v. drip in 2h;5—Fu 500mg/m~2 was give i. v. drip strating while CF was given half way. The treatments were repeated for 5 day , and the course was repeated after 21 days. Results: PR was 19.05%(4/21), MR 23. 81%(5/21), SD 19.05%(4/21), PD 38. 09%(8/21). In all but three progressive cases the clini- cal symptoms were alleviated and the life quality was elevated after this chemotherapy schedule. Median Follow—up of all patient was 8 months, 2 case has survivel for 13,17 months, respec- tively. The commonest side—effects were gastrointestinal reaction, anorexia (71.4%), stomati- tis (38.1%), nauseaveomiting(23.8%), diarrhea (19.0%), myelosuppression all were grade Ⅰ ~Ⅱ,the other symptoms were skin pigmentation ect. conclusions: advanced digestive tract can- cet patient could tolerate this treatment well, survavil prolong.

  • 【会议录名称】 第六次全国大肠癌会议暨中日韩大肠癌会议论文汇编
  • 【会议名称】第六次全国大肠癌会议暨中日韩大肠癌会议
  • 【会议时间】1998-09
  • 【会议地点】中国黑龙江哈尔滨
  • 【分类号】R735.35
  • 【主办单位】中国抗癌协会大肠癌专业委员会
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