【作者】 郑涛； 陈伟； 白桦；

【Author】 Zheng Tao Chen Wei Bai Hua Dpet. of oncological medicine, the people’s Hospital Shen Zhen 518020

【机构】 深圳市人民医院肿瘤科；

【摘要】 目的联合应用醛氢叶酸钙(CF)与氟脲嘧啶(5—Fu),观察该方案对转移性结肠癌的临床疗效和不良反应。方法采用CF每次200毫克,静滴2小时,5—Fu每次500mg／m~2,于CF滴注一半时静脉推注,每天一次,连用5天,21天后重复。结果PR4例(19.05％)、MRS例 (23.81％)、SD4例(19.05％)、PD8例(38.09％)。21例中除3例因病情恶化终止治疗,余18例化疗后临床症状均有减轻或消失,生活质量提高。随访中位生存期8月,有2例至今分别存活13个月、17个月。不良反应以胃肠道多见,其中食欲不振71.40％,口腔溃疡38.10％,恶性呕吐 23.80％,腹泻19.00％,骨髓抑制轻微,均为1～2级毒性反应,其它尚有皮肤色素沉着等。结论 CF加5—Fu联合治疗晚期结肠癌,疗效优于单用5—Fu,同时不良反应较小,患者多能耐受,并可减轻症状,提高生活质量及延长生存期．值得进一步研究。更多还原

【Abstract】 Purpose To observed the results and the side—effect of combination of CF and 5 —Fu regimen in patient with advanced colon cancer. Method: CF200mg i, v. drip in 2h;5—Fu 500mg/m~2 was give i. v. drip strating while CF was given half way. The treatments were repeated for 5 day , and the course was repeated after 21 days. Results: PR was 19.05％(4/21), MR 23. 81％(5/21), SD 19.05％(4/21), PD 38. 09％(8/21). In all but three progressive cases the clini- cal symptoms were alleviated and the life quality was elevated after this chemotherapy schedule. Median Follow—up of all patient was 8 months, 2 case has survivel for 13,17 months, respec- tively. The commonest side—effects were gastrointestinal reaction, anorexia (71.4％), stomati- tis (38.1％), nauseaveomiting(23.8％), diarrhea (19.0％), myelosuppression all were grade Ⅰ ～Ⅱ,the other symptoms were skin pigmentation ect. conclusions: advanced digestive tract can- cet patient could tolerate this treatment well, survavil prolong.更多还原