【作者】 朱曦； 陈静； 刘雷； 李宏亮； 刘少轩； 林崇熙； 徐怡庄； 吴瑾光；

【Author】 ZHU Xi~1 CHEN Jing~2 LIU Lei~2 LI Hong-liang~1,LIU Shao-xuan~2 LIN Chong-xi~2 XU Yi-zhuang~2 WU Jin-guang~2 1.Intensive Care Unit,Peking University Third Hospital,Beijing 100083,China 2.The State Key Laboratory of Rare Earth Materials Chemistry and Applications,College of Chemistry and Molecular Engineering,Peking University.Beijing 100871,China

【机构】 北京大学第三医院危重医学科； 北京大学化学与分子工程学院；

【摘要】 使用~1H核磁共振波谱学对感染性休克合并多器官衰竭病人的血透液加以初步研究。由于血透液是含有数十种溶质的复杂溶液,为了简化分析,我们使用氯仿对经浓缩的血透液进行萃取。核磁共振波谱表明,使氯仿萃取的血透液谱图大为简化。在谱图上可以观察到一系列化学位移在12～15 ppm的谱峰。根据文献报道,这些谱图来自羧酸或酚类的活泼氢。进一步的工作正在进行中。更多还原

【Abstract】 In the present paper,a preliminary investigation by using ¹ H NMR spectroscopy was conducted on the hemodialysate sample from a patient with multiple system organ failure（MSOF） caused by extensive inflection.The hemodialysate is an aque- ous solution containing more than 70 chemical species.To simplify the analysis procedure,the hemodialysate was concentrated and extracted by using CHCl₃.The resultant ¹H NMR spectrum of the hemodialysate extracted by CHCl₃ is significantly simpli- fied in comparison with that of the concentrated hemodialysate.Several strong peaks whoseδis between 12 and 15 ppm can be observed in the ¹H NMR spectrum of the extracted solution.According to the literature,these peaks can be assigned to proton atoms attached to phenol proton or carboxyl groups.The results demonstrate that NMR spectroscopy may enhance our under- standing of the pathology of MSOF at a molecular level.Further studies are still being performed.更多还原