【作者】 李慧珍； 高秀香； 许振华； 刘雷； 林崇熙； 徐怡庄； 吴瑾光；

【Author】 LI Hui-zhen~(1,2) GAO Xiu-xiang~1 XU Zhen-hua~1 LIU Lei~1 LIN Chong-xi~1 XU Yi-zhuang~(1*) WU Jin-guang~1 1.The State Key Laboratory of Rare Earth Materials Chemistry and Applications,College of Chemistry and Molecular Engineering,Peking University,Beijing 100871,China 2.College of Chemistry and Environmental Science,Henan Normal University,Xinxiang 453007,China

【机构】 北京大学化学与分子工程学院,稀土材料化学及应用国家重点实验室； 河南师范大学化学与环境科学学院；

【摘要】 研究了氧氟沙星（ofloxacin,简称OFL）在不同浓度硫酸溶液中的核磁共振波谱和质子化作用。在浓硫酸溶液中,OFL分子的共轭程度大幅度减小,荧光发射波长为400 nm。NMR实验结果表明,哌嗪环的1′N被质子化,造成分子的共轭π电子云发生重排,从而导致¹H NMR,¹³C NMR,¹¹F NMR谱及J_CF发生不同程度的变化。更多还原

【Abstract】 Systematic NMR spectroscopic investigation on ofloxacin in a series of strong sulfuric acid was carried out via ¹H NMR,¹³C NMR,¹⁹F NMR.In concentrated sulfuric acid,the maximal emission wavelength of OFL was at about 400 nm.Fur- ther analysis demonstrates that the above change arises from the variation of protonation states of OFL molecule.As a result, theπelectron cloud of the conjugated system of the OFL molecular rearranged,and the ¹H NMR,¹³C NMR,¹⁹F NMR and J_CF of OFL changed remarkably.The experiments results demonstrated that theδH exhibited different shift to low field while some of theδ_C shift to high field significantly.Such variations were related to the changes of the protonation state of 1′N.更多还原