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甘草次酸与血清白蛋白的结合与其药理意义

Binding of Glycyrrhetinic acid to bovine serum albumin and its pharmacological significance

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【作者】 周能梁逸曾王平陈宪

【Author】 Neng Zhou, Yi-Zeng Liang*, Ping Wang, Xian Chen College of Chemistry and Chemical Engineering, Research Center of Modernization of Chinese Medicines, Central South University, Changsha, 410083,P.R. China

【机构】 中南大学化学化工学院中药现代化研究中心

【Abstract】 Licorice is the most widely used crude drug in traditional Chinese medicine. It is of significance to make a synthetical research on it. Previous studies focus on pharmacology and matter basis. In this paper, serum pharmacology of Glycyrrhetinic acid was studied. The results show it has high affinity to bovine serum albumin and the binding force is hydrophobic. This will exert a big effect on the free concentrations of other bioactive components.

  • 【会议录名称】 中国化学会第二十五届学术年会论文摘要集(下册)
  • 【会议名称】中国化学会第二十五届学术年会
  • 【会议时间】2006-07
  • 【会议地点】中国吉林长春
  • 【分类号】R285
  • 【主办单位】中国化学会
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