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原子力显微镜观察反义核苷酸-磁性纳米粒子复合体诱导HL-60细胞凋亡
AFM Observation of Apoptosis of HL-60 Cells Induced by complex of Antisense Oligonucleotides and Magnetic Nanoparticles
【Author】 De-Hong Long, Long-Zhang Zhu, Ya-Ming Dong, Neng-Qin Jia, He-Bai Shen* Life and Environment Science College, Shanghai Normal University, 200234, Shanghai
【机构】 上海师范大学生命与环境科学学院；
【Abstract】 To explore the anti-tumor activity of human telomemse RNA antisense oligonucleotide (ASO) to 1eukemic cells. The complex of Antisense Oligonucleotides and Magnetic Nanoparticles were exploited to transfect the human leukemia cells(HL-60). The apoptotic morphology changes of the HL-60 cells were observed using AFM technology (Fig.1). Apoptosis was analyzed by flow cytometry. The AFM observations offer new evidence on studying the apoptosis of tumor cells .
【关键词】 磁性纳米粒子-反义寡核苷酸复合体；
HL-60细胞；
凋亡；
原子力学显微镜；
【基金】 国家自然科学基金(No.20443005);上海纳米专项(No.0352nm123)资助
- 【会议录名称】 中国化学会第二十五届学术年会论文摘要集（上册）
- 【会议名称】中国化学会第二十五届学术年会
- 【会议时间】2006-07
- 【会议地点】中国吉林长春
- 【分类号】R733.7
- 【主办单位】中国化学会