【作者】 焦勇； 韩大雄； 杨频；

【Author】 Yong Jiao, Da-Xiong Han, Pin Yang* Institute of Molecular Science, Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education, Shanxi University, 030006,Taiyuan

【机构】 山西大学分子科学研究所化学生物学与分子工程教育部重点实验室；

【Abstract】 Aggregation of amyloid β-peptide (Aβ) into insoluble fibrils is a key pathological event in Alzheimer’s disease (AD). As strong inhibiting Aβ aggregation by competing with Zn(II) for histidine residues, Cu(II) is a potential factor in the normal brain preventing Aβ from the Zn(II)-induced aggregation which carrys out significantly even at the physiological concentrations of Zn(II) in vitro. The possible mechanism of Cu(II) inhibitory effect is investigated for the first time by molecular modeling.更多还原