【作者】 洪青标； 周晓农； 孙乐平； 吴锋； 杨国静；

【Author】 HONG Qingbiao ZHOU Xiaonong SUN Leping WU Feng YANG Gujing Jiangsu Institute of Schistosomiasis,Wuxi 214064

【机构】 江苏省血吸虫病防治研究所；

【摘要】 为研究赤桉提取物（EcM2）与氯硝柳胺及其可湿性粉剂的联合杀螺作用,采用浸杀法,将不同浓度的氯硝柳胺、氯硝柳胺可湿性粉剂分别同不同浓度的 EcM2溶液复配；并将氯硝柳胺与 EcM2、氯硝柳胺可湿性粉剂与 EcM2按不同比例混合。在25±1℃恒温条件下浸泡钉螺48h和72h,观察钉螺死亡情况。结果显示．氯硝柳胺与10mg·L^-1 EcM2配伍后。其对钉螺72h的 LC₅₀由单用时的0．11mg·L^-1 降低为0．0236mg·L^-1,增效比为4．7倍；而同 EcM2按1：100和1：200的比例混合后,两药的共毒系数 （CTC）为162．9和157．2。氯硝柳胺可湿性粉剂与10mg·L^-1 EcM2配伍后,其对钉螺48h的 LC₅₀由单用的0．19mg·L^-1降低为0．074mg·L^-1。增效比为2．56倍；而同 EcM2按1：25和1：50的比例混合后,两药的共毒系数（CTC）为120．8和132．3。共毒系数均超过了100。研究结果表明,从赤桉植物中提取的 EcM2同氯硝柳胺、氯硝柳胺可湿性粉剂配伍混合后,对钉螺具有较强的联合杀螺作用,值得进一步研究。更多还原

【Abstract】 To study the molluscicidal effect of Eucalyptus camaldulensis（EcM2）combined with niclosamide and niclosamide ethanolamine salt wettable powder,the immersion method was taken.Niclosanide and niclosamide ethanolamine salt wettable powder of different concentration were combined with different concentration’s EcM2 solution respectively,and were mixed with EcM2 in different proportion respectively.The snails were immersed at the condition of constant temperature 25±1℃ for 48 hours and 72 hours and then to observe the death of snails. The results showed that the LC₅₀of 72 hours decreased from 0.11mg·L^-1of single using the niclosamide to 0.0236mg·L^-1combined with 10mg·L^-1EcM2.The synergism ratio is 4.7 times.The cotoxicity coefficient （CTC）of nilosamide combined with EcM2 in the proportion of 1:100 and 1:200 is 162.9 and 157.2 respectively. The LC₅₀of 48 hours decreased from 0.19mg·L^-1of sigle using the niclosamide ethanolamine salt wettable pow- der to 0.074mg·L^-1combined with 10mg·L^-1EcM2.The synergism ratio is 2.56 times.The CTC of niclosamide ethanolamine salt wettable powder combined with EcM2 in the proportion of 1:25 and 1:50 is 120.8 and 132.3 respectively.The CTC of all above is over 100.The results suggested that the EeM2 extracted from E. camaldulensis combined with nilousamide and niclosamide ethanolamine salt wettable powder has a strong mollus- cicidal effect.更多还原