【作者】 赵磊； 陈辉； 薛茹； 苏玉忠； 王宏涛； 李军；

【Author】 ZHAO Lei, CHEN Hui, XUE Ru, SU Yuzhong, WANG Hongtao, LL Jun (Department of Chemical and Biochemical Engineering, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005)

【机构】 厦门大学化学工程与生物工程系；

【摘要】 以超临界流体增强溶液分散技术为基础,用N2取代CO2以实现该过程更好的雾化效果。实验研究以聚乙二醇(PEG6000)／丙酮溶液制备PEG微颗粒,探讨预膨胀压力和溶液流量对粒径及粒径分布的影响。结果表明, 超临界N2增强的溶液雾化技术可以制得形态基本上为球形的PEG微粒,并且粒径分布可以方便地控制在1～5 μm。PEG微粒随预膨胀压力增大而减少,粒径分布变窄;低PEG／丙酮溶液流量下制备的微粒粒径分布较窄。更多还原

【Abstract】 On the basis of the solution enhanced dispersion by supercritical fluids (SEDS) technology, polyethylene glycol (PEG6000) micro-particles were generated by using N2 instead of CO2 in order to improve the atomization efficiency. The effects of the pre-expansion pressure and solution flow rate on the produced PEG particles from PEG/acetone solution were investigated. Results showed that the N2 enhanced solution atomization process could produce spherical particles with mean sizes of 1～5 μm. Increasing the pre-expansion pressure could narrow the size distributions of the produced particles and evidently decrease the mean sizes. Decreasing the PEG/acetone solution flow rate could narrow the size distributions of the produced PEG particles.更多还原