【作者】 王峰； 谢树森； 陈荣； 闫劢；

【Author】 WANG Feng1 XIE Shusen2 CHEN Rong2 YAN Mai3 1. Department of Physics, Information Science and Engineering College, Ocean University of China, Qingdao, 266071 2. Institute of Laser, School of Physics and Opoelectronics Technology, Fujian Normal University, Fuzhou 350007 3. Department of Electronics and Information, Information Science and Engineering College, Ocean University of China, Qingdao, 266071

【机构】 中国海洋大学物理系； 福建师范大学激光研究所； 中国海洋大学电子工程系；

【摘要】 白血病是一种高发的恶性肿瘤。自体骨髓移植(ABMT)的研究迅速发展,成为治疗白血病的一种重要手段,但骨髓中残留的白血病细胞的体外净化尚未解决。光动力学疗法(PhotodynamicTherapy,PDT)是一种治疗恶性肿瘤的新方法。利用光动力效应可以选择性的杀死白血病细胞。PDT中辐照光剂量的选择非常重要。本实验采用一种新型的光敏剂—酞菁锌(ZnPcS2P2),用不同的辐照光剂量对K562白血病细胞进行实验,结果发现光剂量不能无限的增加,过高的光剂量在非光动力效应下也会引起细胞的凋亡。更多还原

【Abstract】 The leukemia is a incident malignant tumor. Investigation of autologous bone marrow transplantation(ABMT) is developing rapidly, and ABMT has been a important means to treatment of leukemia, but the purify in vitro of rudimental leukemia cells in marrow has not been solved. Photodynamic therapy(PDT) is a new method to treatment of malignant tumor. Leukemia cells can be killed selectively by photodynamic effect. The selection of light dose in PDT is very important. In this experiment,different light doses were used to kill K562 leukemia cells with ZnPcS2P2. K562 leukemia cells can be killed with higher light dose but this influence is not result of photodynamic effect.更多还原