【作者】 张镇西； 徐正红； 王晶； 黄诒焯；

【Author】 XU Zheng-hong1,2, ZHANG Zhen-xi1, WANG Jing1, HUANG yi-zhuo1 (1. The School of Life Science and Technology, Xi’an Jiaotong University, Xi’an ,China 710049) (2. The School of Electrical Engineering, Xi’an Jiaotong University, Xi’an, China 710049)

【机构】 西安交通大学生命科学与技术学院；

【摘要】 心脏电活动的光学标测技术是将心肌细胞膜电位变化转化成光学信号进行记录的一种新的功能成像技术,是从细胞水平上通过心肌细胞动作电位及其在细胞间传播的电特性来研究心脏电兴奋的传导。它不仅可以多位点、同步、无损地记录心肌细胞群的膜电位变化,测量细胞与细胞间的电传导,而且可以记录全心脏的电活动,并转化为细胞动作电位以及除极、复极等势图或等时图等彩色的功能图像显示。这一技术涉及多项学科,也可以用于“定量神经电生理学”和“脑功能成像”等领域的研究,为进一步研究人体生理、病理和临床医学诊断提供了一种新手段。更多还原

【Abstract】 High-resolution optical mapping with voltage-sensitive dyes is recording the changes of fluorescence intensity that are directly proportional to the changes of tranmembrane potentials from the level of cellular to the whole heart. By using optical recording it is possible to overcome several limitations of other conventional mapping techniques and to depict complex propagation patterns of cardiac transmembrane potentials, and it has become a powerful tool and widely applied to unsolvable problems of cardiac electrophysiology. In this paper, merits and recent progresses on this study were summarized, two types of devices in this field were compared, and the future research interests were also prospected.更多还原