Investigating genetic damage in workers occupationally exposed to methotrexate

【作者】 何继亮；

【机构】 浙江大学医学院公卫系环卫室；

【摘要】 <正>In this article, the genetic damage at 3 genetic endpoints in the workers occupationally exposed to antineoplastc drug was studied with micronucleus test, comet assay, hprt gene mutation assay and TCR gene mutation assay. The subjects were divided into two groups: (1) 21 workers from a plant to produce antineoplastic drug (methotrexate, MIX); (2) 21 controls were matched according to age, gender and smoking. Fresh blood samples更多还原