【作者】 姚琛； 李新松； 吴殊斌；

【Author】 Yao Chen Li Xinsong Wu Shubin(Department of Chemistry and Chemical Engineering, Southeast University,Nanjing,210018) ( Biomaterials and Drug Delivery Laboratories, Southeast University,Nanjing,210018)

【机构】 东南大学化学化工系；

【摘要】 本文对生物可吸收聚(丙交酯-co-乙交酯)(Poly(lactide-co-glycolide),PLGA)与β-磷酸三钙(β-TCP)复合物体系进行了电纺。研究了PLGA的浓度,β-TCP与PLGA比例,电压,喷头与接收体之间的距离,加料速度等因素对电纺过程的影响,制备出纳米纤维膜,并用扫描电镜(SEM)等对纤维膜进行表征。结果表明,电纺溶液浓度越高,或者加料速度越快,纳米纤维的直径越粗。力学实验显示,复合物中β-TCP的含量增加使纳米纤维膜的拉伸强度和杨氏模量下降。更多还原

【Abstract】 Bioresorbable nanofiber mats of poly(lactide-co-glycolide)/β-tricalcium phosphate composite ( PLGA/β-TCP) were electrospun. The effect of polymer concentration, β-TCP/PLGA ratio, distance between the tip and the receiver, voltage, and feed rate on the nanofiber mats were investigated. The nanofiber mats were characterized by scanning electron microscopy (SEM). The higher the concentration was, the bigger the diameter of nanofibers. The tensile strength and Young’ s modulus of the membrane are lowered with increasing the content of β-TCP.更多还原