【作者】 王金勇； 王小龙； 向瑞平； 孙卫东；

【Author】 Wang Jinyong Wang Xiaolong* * Xiang Ruiping Sun Weidong (College of Veterinary Medicine, Nanjing Agric Univ, Nang Jing 210095)

【机构】 南京农业大学动物医学院；

【摘要】 AA肉鸡180羽随机等分为对照组（C）、试验组（A、B）.参试鸡14日龄前常规饲养.14日龄后C组鸡继续常规饲养;A、B鸡舍温度按每日1～2℃由25℃逐步降至12℃,同时日粮中添加1.5mg/kg三碘甲腺原氨酸（T₃）以诱发腹水综合症;B组自14日龄起至试验结束在日粮中再添加1%（质量分数）L-精氨酸.分别于3,4,5,6,7周龄测定各组肉鸡肺动脉平均压（mPAP）、红细胞压积、右心全心比及血浆一氧化氮（NO）水平,并记录腹水发病率.结果发现:低温添加T₃处理后,A组肉鸡腹水发病率增加,mPAP在5周龄时升高,右心全心比在6周龄时升高;B组肉鸡腹水发病率明显低于A组,血浆NO水平高于A组（P<0.01）,mPAP在6周龄时升高,右心全心比在7周龄时升高,此变化比A组晚一周出现.上述结果提示,日粮添加精氨酸后血浆NO水平升高,可能在一定程度上抑制了肺动脉高压的形成,因而在一定程度上降低了腹水综合症发病率.更多还原

【Abstract】 One hundred and eighty AA broilers were divided equally into control (Croup C) and two experiment groups (A,B). Broilers in experiment groups before 14 days of age and group C were fed a normal diet. In experiment groups, broilers were subjected to a change of temperature by lowering 1 -2℃ per day from 25℃ (day 14) down to 12℃ , and then maintained at this ambient temperature until 7 weeks of age. At the same time 1.5 ppm 3,3,5- triiodothyronine(T3) was added to diet of group A in order to induce pulmonary hypertension syndrome (PHS) , and 1.5 ppm T3 with 1 % L - arginine to diet of group B with the purpose of decreasing the incidence of PHS. Moreover,mean pulmonary arterial pressure (mPAP),PCV, RV/TV and plasma nitric oxide (NO) were determined at the age of 3,4,5,6 and 7 weeks, and ascites morbidity was recorded every week. It was found that ascites morbidity in group A was higher than Band C, mPAP in group A was higher than group C(P<0.05) from the fifth week and RV/TV got a significant increase from sixth week (P < 0.05). Plasma NO in group B was higher than that in group A from the third week (P < 0.05), RV/TV and mPAP in group B also got an increase just as group A, but the changes delayed one week later than group A. It was suggested that the increase of NO by L - arginine supplememtation could delay the pathophysiological process leading to the occurrance of PHS.更多还原