【作者】 尹玉琴； 李莹； 徐贵丽；

【Author】 Yin Yuqin1,Li Ying 2,Xiu Guili1(1.Kunming General Hospital of Chengdu Military Region,Kunming 650032,China;2.Gui yang of Pharmacy,gui yangUniversity,Gui yang55000)

【机构】 成都军区昆明总医院； 贵阳医学院药学院；

【摘要】 目的:分析14例骨髓移植患者术后环孢素A(CsA)的有效血药浓度范围,探讨其临床有效性和安全性,为临床更好地合理使用CsA提供参考。方法:采用免疫分析方法对14例骨髓移植患者术后1～466d全血谷浓度进行监测,共216次,并对监测结果进行分析。结果:慢性粒细胞性白血病患者术后CsA的有效血药浓度范围为:50～450ng/ml。急性非淋巴细胞白血病患者术后CsA的有效血药浓度范围为100～450ng/ml。急性淋巴细胞白血病患者术后CsA的有效血药浓度范围为100～350ng/ml。地中海贫血患者术后CsA的有效血药浓度范围为200～500ng/ml。全血细胞减少症患者术后CsA的有效血药浓度范围为250～500ng/ml。骨髓移植术后7例出现排斥反应的谷浓度为67.4～189.34ng/ml(平均125.44±39.56ng/ml)。3例发生不良反应的谷浓度为412.5～548.62ng/ml(平均481.39±68.08)。结论:及时跟踪监测患者CsA血药浓度,调整用药方案,可避免排斥反应和不良反应的发生。对确保患者用药安全有效具有重要的意义。更多还原

【Abstract】 objective:To analyze the suitable dose and effective blood concentration of cyclosporine A by monitoring the blood concentration of patients after allogeneic hem atopoietic stem cell transplantation in 14,and to supply the theoretic basis for clinical rational administration of drug,which may be used for studying the efficacy and safety in the clinic.Methods:216 cases’ cyclosporin A blood concentrations in 14 allogeneic hem atopoietic stem cell transplant recipients were determined by the fluorescence polarization immunoassay,the results were analyzed.Results:The CML patients’ CsA blood concentration was(50～450)μg/ml.The AML patients’ CsA blood concentration was(100～450)μg/ml.The ALL patients’ CsA blood concentration was(100～ 350)μg/ml.The Thalassemia patients’ CsA blood concentration was(200～500)μg/ml.The IRP patients’ CsA blood concentration was(250～500)μg/ml.valley density(67.4～189.34)ng/ml,the average was(125.44±39.56)ng/ml(n=7).ng/ml in which the patients appeared rejection reaction.The valley density was(412.5～548.62)ng/ml,the average was(481.39±68.08)ng/ml(n=3),in which the patients after allogeneic hem atopoietic stem cell transplantaion appeared adverse drug reaction.Conclusion:Monitoring cyclosporin A blood concentration,using medicine in time,it can less rejection and durg reaction,ensure the patients in their safe and effective use of drug is significant.更多还原