【作者】 许东晖； 王胜； 金晶； 梅雪婷； 罗小菊； 许实波；

【Author】 (Lab. of Traditional Chinese Medicine and Marine Drugs, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510275, China)

【机构】 中山大学药学院中药与海洋药物研究室；

【摘要】 目的聚乙烯吡咯烷酮(PVP)k30固体分散体系对姜黄素的增溶作用。方法选择PVPk30作为载体,用溶剂法制备姜黄素固体分散体;通过差示扫描量热分析和X射线粉末衍射以鉴别姜黄素在载体中的存在状态以及与载体之间的相互作用,并采用紫外-可见分光光度法测定姜黄素固体分散体的溶解度以及体外溶出度。结果成功制备了姜黄素的固体分散体;紫外-可见分光光度法测定姜黄素的溶出量,其结果准确可靠、稳定、无载体的干扰。与姜黄素本身相比,固体分散体中姜黄素溶解度提高了880倍以上,溶出速度明显增大。结论PVPK30可作为载体用以提高姜黄素溶解度及溶出速度。更多还原

【Abstract】 Aim To enhance the solubility and dissolution rate of curcumin. Methods Solid dispersion systems of curcumin in PVPK30 were prepared at various weight ratios by co-evaporation of curcumin and PVPk30 ethanol solution. The DSC(Differential Scanning Calorimetry) and Powder X-ray Diffractometer method were used to describe the status of curcumin in carriers, the UV spectrometry method for determination of curcumin in mediums was established. Results The solid dispersion of curcmin was successfully prepared, the UV spectrometry method was accurate and reliable, and no interference occurred from carrier. Both the solubility and the dissolution rate in vitro of curcumin were significantly raised, compared with curcumin, the solubility of solid dispersion increased at least 880 folds. Conclusion The solid dispersion in PVPk30 improves well the solubility and the dissolution rate of curcumin.更多还原