【作者】 吴晓松； 徐珍霞； 张志东；

【Author】 Wu Xiao-Song, Xu Zhen-Xia, Zhang Zhi-Dong,et al(The First Affiliated Hosptial of Jinan University,Guangzhou 510630,China)

【机构】 暨南大学附属第一医院； 暨南大学药学院；

【摘要】 目的对乙酸龙脑酯滴丸的制备工艺进行研究。方法采用正交实验法研究滴丸成型的最佳工艺条件。结果以选择PEG4000:PEG6000(2:1)混合液作为基质,药物:基质以1:4配比,料温为70℃,液体石蜡为冷却剂,冷凝液温度为10℃,滴口内外径为2.5/2.9(mm/mm),滴口距冷凝液面3cm,滴速为40d/min。为最佳条件。结论该工艺可为乙酸龙脑酯滴丸的制备提供实验依据。更多还原

【Abstract】 Objective To study the technical preparation of Bornyl Acetate dropping pills. Methods:Orthogonal test was applied to optimize the preparation of Bornyl Acetate dropping pills. Results The optimized project was as follow: the matrix contained PEG4000:PEG6000(2:1); the rate of Bornyl Acetate to matrix was 1:4and the temperature of limonene was 70℃; the refrigerant was liquid paraffin; the internal and external diameter of burette was 2.5mm and 2.9mm, respectively; the burette was 3cm above the surface of refrigerant; Drug was dropped into refrigerant of 10℃ at 40drops per minute. Conclusion The results provide the data for the ascertainment of shaping operation of Bornyl Acetate dropping pills at the manufacturing scale.更多还原