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中药提取物微囊化防潮技术及其机理研究

Influencing Factors on Dampproof Effect of Microcapsules and Study on Mechanism

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【作者】 冯怡刘怡徐德生

【Author】 Feng Yi, Liu Yi, Xu De-sheng (Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China)

【机构】 上海中医药大学

【摘要】 目的考察喷雾干燥工艺对鞣质微囊防潮效果的影响,并研究了造成影响的机理。方法喷雾干燥制成的鞣质微囊置于一定温湿环境中12h,绘制吸湿曲线以研究进风温度、供液速度、雾化气流速与微囊防潮效果间的规律;并从微囊溶剂残留量、成膜过程膜收缩行为和微囊粒径3个方面研究造成这些规律的机理。结果微囊防潮效果随着进风温度的提高、供液速度的降低、雾化气流速的降低而增强;反之则减弱。造成这种影响是由于成囊过程中囊壁致密程度、微囊中溶剂残留以及微囊粒径不同而造成的。结论喷雾干燥制备微囊不同工艺参数制得的微囊的物理状态不同,其防潮效果也不同。

【Abstract】 Objective The influence of spray drying technology on the damp proof effect of microcapsules and the mechanism were studied. Method The microcapsules prepared with different spray drying parameters have been put in certain surroundings for 12 hours, then the hygroscopic curves were gotten; the mechanism was studied from the following aspects: solvent residue, film’s shrink and particle size. Result The damp proof effect enhanced with the increase of inlet air temperature and the decrease of flow rate and air pressure. The properties of the wall, the solvent residue and particle size can influence the damp proof effect of the microcapsules. Conclusion The physical properties of microcapsules are different because of the different spray drying parameters, which lead to different dampproof effect of microcapsules.

  • 【会议录名称】 2006第六届中国药学会学术年会论文集
  • 【会议名称】2006第六届中国药学会学术年会
  • 【会议时间】2006-11
  • 【会议地点】中国广东广州
  • 【分类号】TQ461
  • 【主办单位】中国药学会
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