【作者】 陈鹰； 李高； 王瑞华；

【Author】 Chen Ying ,Li Gao ,Wang Rui-hua (School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030,China)

【机构】 华中科技大学同济医学院药学院；

【摘要】 目的:研究长春西汀自乳化释药系统(VIN-SEDDS)的体外释药特性。方法:进行了体外释放度实验,考察释放度实验方法学、释放介质、转速和制剂因素对药物释放特性的影响。结果释放度实验方法学、释放介质、转速和制剂处方因素都会对药物释放测定结果造成影响。采用反相透析技术能较好地模拟口服后的体内生理情况,在人工肠液中,转速50r·min-1下,VIN-SMEDDS累积释放百分率3h达到68.45%。SMEDDS制剂的电性对释放基本无影响,VIN-SMEDDS的体外释放比VIN-SEDDS好。结论长春西汀自乳化释药系统显著提高了药物的释放速度和程度。体外反相透析释放实验的透膜限速过程属于被动扩散过程。更多还原

【Abstract】 Objective:To study the release characters in vitro of Vinpocetine self- microemulsifying drug delivery system (VIN-SEDDS). Method:The dissolution in vitro of VIN-SEDDS were determined. And the effects of different dissolution methods, dissolution media, rotational speeds and preparations on release characters of drug were studied. Result: The release characters in vitro of drug were inflenced by different dissolution methods, media, rotational speeds and preparations. The reverse dialysis bag technique could preferably simulate the situation of oral drug. The cumulative disslotion ratio of VIN-SMEDDS at 3h in PH6.8 PBS under 50 r·min-1 reached 68.45%. And the potention of SMEDDS almost had no effects on the dissolution tests. The cumulative disslotion ratio of VIN from SMEDDS was higher than that from SEDDS. Conclusion: The formulation of VIN-SEDDS can significantly improve the dissolution of vinpocetine. The process of the drug penetrating membrane with reverse dialysis technique fits passivediffusion.更多还原