【作者】 童卫杭； 柴栋； 李朝霞； 王睿；

【Author】 TONG Wei Hang , CHA IDong, LI Zhao Xia, WANG Rui ( The Chinese PLA General Hospital, B eijing 100853, China)

【机构】 解放军总医院临床药理室； 解放军总医院呼吸科；

【摘要】 目的评价头孢吡肟与舒巴坦对临床分离碳青霉烯耐药不动杆菌属细菌的体外联合抗菌效应。方法:采用棋盘法设计,微量肉汤稀释法测定。测定不同浓度组合的抗菌药物对24株临床分离的耐碳青霉烯不动杆菌属细菌的最低抑菌浓度,并计算FIC指数判定联合效应。结果:头孢吡肟 /舒巴坦联合应用后,其MIC50明显降低。FIC指数≤0．5占33.3％,0．5<FIC≤1,占62．5％,1<FIC ≤2占4．2％,FIC>2为0。结论:头孢吡肟／舒巴坦联合用药对临床分离碳青霉烯耐药鲍曼不动杆菌体外联合抗菌效应主要表现为协同作用。更多还原

【Abstract】 Objective: To assess the in vitro activity of Cefepime combined with Sulbactam against Carbapenem-resistant strains of Acinetobacter.spp clinical isolated. Methods: The activity of each drug alone was determined against all the isolates. Chequerborad synergy testing was then performed against all the isolates. Results: The percentage of the FIC index show 33.3% synergism, 62.5% additive, 4.2% (1/24) indifference, and no antagonism lively. Conclusion: Testing of Cefepime and Sulbactam combinations revealed Synergism and additivity activity against some Carbapenem-resistant strains of Acinetobacter.spp which could be likely to prove beneficial for the treatment of infections due to ultidrug-resistant strains of Acinetobacter.spp.更多还原