【作者】 谢晟； 郭雪梅； 崔爱国； 肖江喜； 蒋学祥；

【机构】 北京大学第一医院放射科；

【摘要】 目的应用弥散张量成像对儿童脑室周围白质软化症患儿和正常要幼儿进行比较。方法对15例正常志愿者和15例PVL患儿进行了弥散张量成像扫描,测量双侧内囊后肢、双侧视放射和胼胝体膝部、压部的部分各向异性FA值,并对结果进行统计学比较。结果对照组和PVL组的双侧内囊后肢、双侧视放射和胼胝体膝部、压部的部分各向异性均存在显著性差异(P<0.01)。结论弥散张量成像能提示纤维束的髓鞘化过程的延迟,反映儿童发育中脑白质微观结构的改变,在PVL的随访观察中具有较大的潜力。更多还原

【Abstract】 Objective To compare pediatric patients with periventricular leukomalacia (PVL) with normal children u-sing diffusion tensor imaging. Methods Diffusion tensor images were obtained in 15 pediatric patients with PVL and 15 age-matched normal children. Regions of interest were drawn to measure the fractional anisotropy (FA) of bilateral posterior limb of internal capsule, bilateral optic radiation, genu of corpus callosum and splenium of corpus callosum. The values of PVL patients and normal children were compared using non-dependent samples t-test. Results The FA values of regions of interest prescribed were significantly lower in PVL patients than in normal children (P<0. 01). Conclusion Diffusion tensor imaging may reveal retard of myelienation of fiber tracts in PVL patients. It can be a potential tool in e-valuating the brain development of children.更多还原