【作者】 王敏； 戴志坚； 王厚军；

【Author】 Wang Min Dai Zhijian Wang Houjun (Department of Automation Engineering,University of Electronic Science and Technology of China,Chengdu 610054,China)

【机构】 电子科技大学自动化工程学院；

【摘要】 本文是针对生物信号分析系统中关于药物代谢动力学分析方法进行的研究。线性动力学模型是药物代谢动力学中使用最为广泛的一种模型,一般采用最小二乘法估计模型参数。为了解决最小二乘法中参数初值难以估计的问题,本文结合残差法和最小二乘两种方法的优点提出了使用残差法估计参数初值的方法,加快了迭代速度,提高了参数估计的准确度。更多还原

【Abstract】 This paper is about the study that how to find the exact value of parameter in the linear dynamic model used in pharmacokinetic widely.Least squares arithmetic is the method which always be used to solve this problem.But the difficulty of using this method is how to determine the initial value of estimate about the parameters.In order to overcome the difficulty,this paper proposes to use the residual method to initialize the value,based on the merits of both approaching residual method and the least-squares meth- od.The application of the method accelerates the iterative speed,improves the accuracy of value of estima- tion about the parameters.更多还原