【作者】 肖强； 屠鹏飞； 崔育新；

【Author】 Qiang Xiao Pengfei Tu Yuxin Cui (School of Pharmaceutical Sciences,National Laboratory of Natural and Biomimetic Drugs,Medical and Health Analysis Center,Peking University,Beijing 100083)

【机构】 北京大学药学院天然药物及仿生药物国家重点实验室,医药卫生分析中心；

【摘要】 <正>1993年,Paris 等人发现鼠尾草酸具有明显的抑制 HIV-1蛋白酶和 HIV 病毒复制的作用,这一工作引起了许多化学家们的研究兴趣。在我们寻求新的抗 AIDS 药物的过程中,需要研究该类天然产物的构效关系,为此而设计了一条新的全合成路线。在全合成(±)Pisiferic Acid 时由于对化合物(1)关环条件的差别得到了完全不同的产物。更多还原

【Abstract】 In 1993,Paris reported that Camosic acid possess inhibitory effect on HIV- 1 protease and HIV virus replication activity.In our aim to discover and develop new anti-HIV drugs,a new route of synthesis this type compounds was designed.In the course of synthesis Pisiferic Acid that is one of this type natural products,a novel skeleton was discovered and it has a[6,8,6]tricycle, which is a dynamic product.Its structure has been confirmed on the basis of spectral evidence,especially by 2D-NMR（¹H-1H COSY,HMQC,HMBC）and all of the ¹H and ¹³C NMR chemical shifts were also assigned.更多还原