【作者】 马立斌； 金怡珠； 涂光忠； 洪少良； 罗何生； 赵玉英； 胡长风； 张如意；

【Author】 Ma Libin Jin Yizhu Tu Guangzhong Hong Shaoliang (Beijing Institute of Microchemistry,Beijing 100091) Lao Hesheng Zhao Yuying Hu Changfeng Zhang Ruyi (Department of Phytochemistry,Beijing Medical University,Beijing 100083)

【机构】 北京微量化学研究所； 北京医科大学医学院植化室； 北京医科大学计算中心；

【摘要】 <正>柴胡是中国药典收载的药品.在临床上,柴胡主治感冒,发热,寒热等症.本文报道从小叶黑柴胡(Bupleurum smithii Wolff Var.parvifolium Shan et Y.Li)分离出的一种新皂甙.应用NMR等方法对其结构进行了研究,确定该化合物为3β,16β,23,28-四羟基齐墩果烷-更多还原

【Abstract】 Saikosaponin o was isolated from Bupleurum smithii Wolff Var.parvifolium Shan et Y.Li.Its structure was determined by NMR method.From TOCSY and DQF-COSY spectra,the residues of monosaccharides and all their assignments were acquired. The anomeric configurations were obtained by ¹J_C1H1 and ³J_H1H2.It was difficult to get the ¹³C assignment with CH-COSY onty,therefore,the HMQC-COSY was used for it and was successful.All the glycosidic linkages were obtained from HMBC spectrum based on the ¹H and ¹³C assignments.NOESY spectrum also gave the concordant result about the configurations and the linkages positions.更多还原