【作者】 华松； 武浩； 张涌；

【Author】 HUA Song, WU Hao, ZHANG Yong(Institute of Blo-Engineering,Northwest Sci-Tech University of Agriculture and Forestry, Yangling,Shaanxi, China ,712100)

【机构】 西北农林科技大学生物工程研究所；

【摘要】 骨髓间充质干细胞是存在于骨髓中的除造血干细胞以外的另一类具有多向分化潜能的干细胞。在一定的诱导条件下,这类细胞在体外可定向分化为多种造血以外组织,特别是中胚层和神经外胚层来源的组织细胞,例如成骨细胞、软骨细胞、脂肪细胞、肌肉细胞、肝细胞、神经细胞等。骨髓间充质干细胞具有贴壁生长的特性,在体外易分离和扩增,还易于外源基因的转入和表达,在人类医学上被认为是一种理想的治疗性细胞和基因治疗中的靶细胞。本文综述了近年来国内外有关骨髓间充质干细胞诱导分化的研究进展。更多还原

【Abstract】 Besides hematopoietic stem cells, bone marrow contains another kind of stem cells called bone marrow mesenchymal stem cells (BMSC) which are with the character of multipotent tissue stem cells. With special induced conditions, BMSC can be induced to differentiate into many types of nonhematopoietic tissue cells. For example osteoblasts, chondroblasts, adipocytes, tendocytes, myoblasts and neurocytes .BMSC can be easily separated from bone marrow and purified in vitro because of their adhesion to plastic. They also have the ability to express many extra transgenes in vitro or in vivo. So BMSC have been regarded as ideal cell resources in cell and gene therapy. In this paper ,the advance in the research of BMSC special defferentiation and their clinical application are reviewed.更多还原