【作者】 屈长青； 姬云涛； 孙超； 李影； 辛亚平； 杨公社；

【Author】 QU Chang-qing, JI Yun-tao, SUN Chao, LI Ying, XIN Ya-ping, YANG Gong-she(1.College of Animal Science and Technology, Northwest Sci-Tech University of Agriculture and Forestry,Yangling, Shaanxi 712100, China)

【机构】 西北农林科技大学动物科技学院；

【摘要】 日粮中的PUFA具有多种作用,除了是膜的结构成分、参与能量代谢过程和细胞信号转导之外,同时还与控制脂肪细胞的增殖和分化、多种与脂肪代谢的酶和蛋白的基因表达有关,从而调控动物的脂肪代谢和体脂沉积。这些调节机制涉及许多转录因子如:PPARα、SREBPs、LXR和HNF-4a等,通过他们来影响靶基因(如:ACO-A、FAS等)的表达。PUFA还可以通过其代谢产物来调控基因的表达。更多还原

【Abstract】 PUFA are important components of membranes and they take part in the process of energy metabolism and signal transduction of cells. They also can control adipocyte differentiation and have effect on the expression of genes encoding enzymes and proteins involved in lipid metabolism. As a result, they can regulate animal lipid metabolism and reduce body fat deposition, there are many transcription factor have been identified as targets for PUFA regulation, including PPAR α , SREBPs, LXR and HNF-4a et al. Additional, the metabolic material of PUFA can decrease expression of lipogenic genes更多还原