【作者】 王勤； 李保陆； 翟云皓； 李新刚； 李刚； 郝晓光；

【Author】 Wang Qin Li Baolu Zhai Yunhao Li Xingang, Li Gang Hao Xiaoguang1 (Institute of Medical Instrument of Shandong province, Ji’nan 250013) 2(Qilu Hospital of Shandong University , Ji’nan 250012)

【机构】 山东省医疗器械研究所； 山东大学齐鲁医院；

【摘要】 以聚乳酸作为缓释基质,与水溶性不能通过血脑屏障的化疗药物盐酸阿霉素制备成聚乳酸—阿霉素缓释制剂,对聚乳酸的生物相容性及细胞毒性进行了研究,对缓释制剂的制备工艺、体内、外的降解及缓释速率等进行了研究,并植入胶质瘤动物模型中进行肿瘤局部间质内化疗,观察其对大鼠皮下胶质瘤的杀伤作用,对其疗效、毒副作用等进行了探索,取得了理想的效果。更多还原

【Abstract】 In our study, poly (lactic acid)(PLA) is used as prolonged-releasing matrix and Doxorubicin is chosed as chemotherapeutic agent, thus the PLA-Doxorubicin prolonged-releasing system was prepared. Its prolonged-releasing capacity was studied by HPLC(High performance liquid chromatography). Its chemotherapeutic effect was observed on S,C C6 glioma model on SD rats. Its degradation in vitro and in vivo, biocompatibility and cell toxicity were also tested and the results were favorable.更多还原