【作者】 刘墨祥； 茆同江； 夏叶玲；

【Author】 LIU Mo-xiang1 MAO Tong-jiang2 XIA Ye-ling1(1.Natural Pharmaceutical Chemistry Lab,Yangzhou University,Yangzhou 225001,China;2.Taizhou Institute of Measurement and Testing Technology,Taizhou 225300,China;)

【机构】 扬州大学医学院； 泰州市计量测试技术研究所；

【摘要】 目的:考察人参皂苷-Rg3微乳剂急性毒性及热原检查情况,判断人参皂苷-Rg3微乳剂是否符合临床使用安全性要求,为临床研究提供依据。方法:采用小鼠尾静脉及腹腔注射给药进行急性毒性试验,采用家兔法进行热原检查。结果:小鼠尾静脉注射LD50为2.52mg/kg±0.28mg/kg,95%可信限为2.24mg/kg～2.80mg/kg;家兔无热原反应。结论:人参皂苷-Rg3微乳剂静脉注射较为安全,可供临床研究试用。更多还原

【Abstract】 Objective:To study the acute toxicity research and pyrogen test of microemulsion ginsenoside-Rg3,which provides the basis for the clinical research.Whether does the microemulsion ginsenoside-Rg3 conform to the clinical operational safety requests? Methods:It Carries on the acute toxicity test by using the mouse tail vein and the abdominal cavity injection.To carry on the pyrogen test by injecting microemulsion ginsenoside-Rg3 to the domestic rabbits Results:Mouse tail intravenous injection LD50 is 2.52 mg/kg±0.28mg/kg;Domestic rabbits have non-pyrogen response.Conclusions :It issafer to inject microemulsion ginsenoside-Rg3,Microemulsion ginsenoside-Rg3 may supply the clinical research test.更多还原