【作者】 陈祥； 钟翎；

【Author】 Chen Xiang Zhong Ling (School of Pharmaceutical Sciences,Sun Yat-sen University,Guangzhou 510080,China)

【机构】 中山大学药学院微生物与生化制药实验室；

【摘要】 淀粉样蛋白沉积(俗称老年斑,senile plague,SP)是阿尔茨海默病(Alzheimer’s disease, AD)最主要病理学特征之一．β淀粉样蛋白(β-amyloid peptides,A β)是老年斑的核心成分．研究表明,Aβ在 AD 的发生、发展过程中起主要作用．Aβ可引起氧化应激反应,诱导记忆损伤,形成离子通道,破坏细胞内外离子平衡,触发炎症反应,引起神经细胞调亡．本文就 Aβ神经毒性作用作一综述．更多还原

【Abstract】 β-amyloid peptides(Aβ)deposition is one of the key pathological features of Alzheimer’s disease(AD).The deposition is composed mainly of Aβ peptides.Numerous reports have provided evidence that Aβ peptides play a key role in the onset and development of AD. Aβ peptides can induce oxidative stress,memory loss,inflammatory reaction and form ion channels in lipid bilayers,which finally leads to neuron apoptosis.This review focuses on the mechanism of neurotoxicity induced by Aβ peptides.更多还原