【作者】 任丹丹； 汪秋宽； 张甜翠； 何云海； 刘远平；

【Author】 REN Dan-dan,WANG Qiu-kuan,ZHANG Tian-cui,HE Yun-hai,LIU Yuan-ping Key Laboratory of Aquatic Product Processing and Utilization of Liaoning Province,College of Food Engineering,Dalian Fisheries University,Dalian 116023,China

【机构】 辽宁省水产品加工及综合利用重点开放实验室大连水产学院食品工程学院；

【摘要】 本文研究了海带岩藻聚糖硫酸酯（FLJ）对S₁₈₀荷瘤小鼠的抑瘤作用。以动物移植性肿瘤小鼠肉瘤S₁₈₀为模型,以环磷酰胺为阳性对照,以蒸馏水为阴性对照,观察100, 500,1000 mg/kg·d的FLJ的体内抑瘤率,及其对荷瘤小鼠脏器指数的影响,对肝脏和血清中MDA,SOD的影响来观察其对荷瘤小鼠免疫系统和抗氧化能力的影响。并采用显微镜观察肿瘤组织形态学变化。结果表明各剂量组的FLJ与阴性对照组相比,对S₁₈₀肉瘤均有较强的抑制作用,对荷瘤小鼠肝脏和血清中MDA含量有降低作用,对SOD活性有增强作用,且FLJ对小鼠免疫系统具有一定的增强作用。FLJ对S₁₈₀荷瘤小鼠的抗肿瘤作用可能与其增强机体免疫和提高抗氧化能力有关。更多还原

【Abstract】 The antitumor activity of fucoidan from Laminaria japonica（FLJ） was studied in this article.Cyclophosphamide is positive control and distilled water is negative control. S₁₈₀-bearing mice were used as animal model.The changes of S₁₈₀ tumor weight in vivo,the changes of viscera index and the changes of MDA content and SOD activity of liver and serum in S₁₈₀-bearing mice were investigated when different dosage FLJ（100,500,1000 mg/kg·d） were administered orally.The histological changes of tumor were observed by optical microscope.It was shown that FLJ can inhibit tumor growth markedly in S₁₈₀-bearing mice compared with negative control group.It can decrease MDA content and increase SOD activity of liver and serum in S₁₈₀-bearing mice.It also can increase thymus index and spleen index of S₁₈₀-bearing mice which showed FLJ could enhance the immune function.The mechanism of its antitumor maybe concerned with its antioxidant effect and effect of immune modulation.更多还原